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Synthesis of substituted pyrimido[4,5-b] and [5,4-c]-[1,8]naphthyridines

✍ Scribed by Christophe Plisson; Jacques Chenault

Publisher: Journal of Heterocyclic Chemistry
Year: 2001
Tongue: English
Weight: 56 KB
Volume: 38
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570380225

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✦ Synopsis

Abstract

Ethyl 1‐ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro[1,8]naphthyridine‐3‐carboxylate (1), precursor of nalidixic acid, has been converted in two steps through ([1,8]naphthyridin‐3‐yl)carbonylguanidine derivatives into substituted pyrimido[4,5‐b] and [5,4‐c][1,8]naphthyridines.

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