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24R,25-Dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1α,25(OH)2D3 in hypertrophic cells

✍ Scribed by B.D. Boyan; J. Hurst-Kennedy; T.A. Denison; Z. Schwartz


Book ID
116698515
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
602 KB
Volume
121
Category
Article
ISSN
0960-0760

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Membrane actions of vitamin D metabolite
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1alpha,25(OH)(2)D(3) regulates rat growth plate chondrocytes via nuclear vitamin D receptor (1,25-nVDR) and membrane VDR (1,25-mVDR) mechanisms. To assess the relationship between the receptors, we examined the membrane response to 1alpha,25(OH)(2)D(3) in costochondral cartilage cells from wild type