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Evidence for distinct membrane receptors for 1α,25-(OH)2D3 and 24R,25-(OH)2D3 in osteoblasts

✍ Scribed by Barbara D. Boyan; Lynda F. Bonewald; Victor L. Sylvia; Ilka Nemere; Dennis Larsson; Anthony W. Norman; Jennifer Rosser; David D. Dean; Zvi Schwartz


Book ID
117213438
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
290 KB
Volume
67
Category
Article
ISSN
0039-128X

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1alpha,25(OH)(2)D(3) regulates rat growth plate chondrocytes via nuclear vitamin D receptor (1,25-nVDR) and membrane VDR (1,25-mVDR) mechanisms. To assess the relationship between the receptors, we examined the membrane response to 1alpha,25(OH)(2)D(3) in costochondral cartilage cells from wild type