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Plasma membrane requirements for 1α,25(OH)2D3 dependent PKC signaling in chondrocytes and osteoblasts

✍ Scribed by Barbara D. Boyan; Liping Wang; Kevin L. Wong; Hanjoong Jo; Zvi Schwartz


Book ID
116891890
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
512 KB
Volume
71
Category
Article
ISSN
0039-128X

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## Abstract Phospholipase A~2~ (PLA~2~) is pivotal in the rapid membrane‐mediated actions of 1,25‐dihydroxyvitamin D3 [1α,25(OH)~2~D~3~]. Microarray analysis indicated that PLA~2~ activating protein (PLAA) mRNA is upregulated 6‐fold before rat growth plate cells exhibit 1α,25(OH)~2~D~3~‐dependent p