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Prostaglandins mediate the effects of 1,25-(OH)2D3 and 24,25-(OH)2D3 on growth plate chondrocytes in a metabolite-specific and cell maturation-dependent manner

โœ Scribed by Z Schwartz; R.M Gilley; V.L Sylvia; D.D Dean; B.D Boyan


Book ID
117808801
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
151 KB
Volume
24
Category
Article
ISSN
8756-3282

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Prior studies have shown that 24,25-(OH) 2 D 3 and 1,25-(OH) 2 D 3 regulate protein kinase C (PKC) in costochondral chondrocytes in a cell maturation-dependent manner, with 1,25-(OH) 2 D 3 affecting primarily growth zone (GC) cells and 24,25-(OH) 2 D 3 affecting primarily resting zone (RC) cells. In