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2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase ‖

✍ Scribed by Hagen, Timothy J.; Bergmanis, Arija A.; Kramer, Steven W.; Fok, Kam F.; Schmelzer, Albert E.; Pitzele, Barnett S.; Swenton, Lydia; Jerome, Gina M.; Kornmeier, Christine M.; Moore, William M.; Branson, Linda F.; Connor, Jane R.; Manning, Pamela T.; Currie, Mark G.; Hallinan, E. Ann


Book ID
126394105
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
172 KB
Volume
41
Category
Article
ISSN
0022-2623

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ChemInform Abstract: 2-Iminopyrrolidines
✍ T. J. HAGEN; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of