ChemInform Abstract: 2-Iminopyrrolidines
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T. J. HAGEN; ET AL. ET AL.
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Article
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2010
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John Wiley and Sons
⚖ 29 KB
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A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of