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3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: A Potent and Highly Selective Inducible Nitric Oxide Synthase Inhibitor.

โœ Scribed by Sofya Tsymbalov; Timothy J. Hagen; William M. Moore; Gina M. Jerome; Jane R. Connor; Pamela T. Manning; Barnett S. Pitzele; E. Ann Hallinan


Publisher
John Wiley and Sons
Year
2003
Weight
146 KB
Volume
34
Category
Article
ISSN
0931-7597

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ChemInform Abstract: 2-Iminopyrrolidines
โœ T. J. HAGEN; ET AL. ET AL. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 2 views

A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of