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2-Iminohomopiperidinium Salts as Selective Inhibitors of Inducible Nitric Oxide Synthase (iNOS)†

✍ Scribed by Peterson, Karen B.; Trivedi, Mahima; Kramer, Steven W.; Webber, Ronald K.; Tjoeng, Foe S.; Moore, William M.; Jerome, Gina M.; Kornmeier, Christine M.; Manning, Pamela T.; Hansen,, Donald W.


Book ID
115470597
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
79 KB
Volume
41
Category
Article
ISSN
0022-2623

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ChemInform Abstract: 2-Iminopyrrolidines
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A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of