A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of
β¦ LIBER β¦
ChemInform Abstract: Selective Heterocyclic Amidine Inhibitors of Human Inducible Nitric Oxide Synthase.
β Scribed by Alan E. Moormann; Sue Metz; Mihaly V. Toth; William M. Moore; Gina Jerome; Christine Kornmeier; Pamela Manning; Donald W. Hansen Jr.; Barnett S. Pitzele; R. K. Webber
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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