ChemInform Abstract: Conformationally Restricted Arginine Analogues as Inhibitors of Human Nitric Oxide Synthase.
β Scribed by B. G. SHEARER; S. LEE; K. W. FRANZMANN; H. A. R. WHITE; D. C. J. SANDERS; R. J. KIFF; E. P. GARVEY; E. S. FURFINE
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of