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Bicyclic Amidine Inhibitors of Nitric Oxide Synthase: Discovery of Perhydro-iminopyrindine (Ia) and Perhydro-iminoquinoline (Ib) as Potent, Orally Active Inhibitors of Inducible Nitric Oxide Synthase.

โœ Scribed by Shrenik K. Shah; et al. et al.


Publisher
John Wiley and Sons
Year
2005
Weight
9 KB
Volume
36
Category
Article
ISSN
0931-7597

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A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of