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The Use of Selective Inhibitors of Inducible Nitric Oxide Synthase in Septic Shock

✍ Scribed by Christoph Thiemermann


Book ID
110281068
Publisher
Springer
Year
1998
Tongue
English
Weight
166 KB
Volume
1
Category
Article
ISSN
1573-7411

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A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of