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2-Iminopiperidine and Other 2-Iminoazaheterocycles as Potent Inhibitors of Human Nitric Oxide Synthase Isoforms †

✍ Scribed by Moore, William M.; Webber, R. Keith; Fok, Kam F.; Jerome, Gina M.; Connor, Jane R.; Manning, Pamela T.; Wyatt, Pamela S.; Misko, Thomas P.; Tjoeng, Foe S.; Currie, Mark G.

Book ID
120491545
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
137 KB
Volume
39
Category
Article
ISSN
0022-2623

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A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of