19F magnetic resonance imaging and spectroscopy of a fluorinated neuroleptic ligand: In vivo and in vitro studies
β Scribed by David C. Arndt; Adam V. Ratner; Kym F. Faull; Jack D. Barchas; Stuart W. Young
- Book ID
- 119095086
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 415 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0165-1781
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## Abstract A new perfluorocarbon, PTBD (perfluoroβ2,2, 2β², 2β²βtetramethβylβ4,4β²βbis(1, 3βdioxolane)), is described for use in ^19^F MR imaging and spectroscopy. Twoβthirds of the molecular fluorine in PTBD resonates at a single frequency and can be imaged without the use of frequencyβselective spi
In viuo 'q NMR measurements of the fluorinated neuroleptic melperone [4'-fluoro-4-(4-methyIpiperidino)butyrophenone hydrochloride] in the rat brain were performed using a geometrically optimized surface coil at 4.7T. It was possible for the first time to detect a signal of a monofluorinated neurolep