A new perfluorocarbon for use in fluorine-19 magnetic resonance imaging and spectroscopy

✍ Scribed by Christopher H. Sotak; Paul S. Hees; Hsu-Nan Huang; Ming-H. Hung; Carl G. Krespan; Stuart Raynolds

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 874 KB
• Volume: 29
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910290206

✦ Synopsis

Abstract

A new perfluorocarbon, PTBD (perfluoro‐2,2, 2′, 2′‐tetrameth‐yl‐4,4′‐bis(1, 3‐dioxolane)), is described for use in ^19^F MR imaging and spectroscopy. Two‐thirds of the molecular fluorine in PTBD resonates at a single frequency and can be imaged without the use of frequency‐selective spin‐echo (SE) MRI pulse sequences to suppress chemical shift artifacts. The absence of strong homonuclear spin‐spin coupling to the imagable ‐CF~3~ groups in PTBD minimizes signal attenuation in ^19^F SE MRI due to J‐modulation effects. For equimolar concentrations of perfluorocarbon, PTBD gives an approximately 17% increase in sensitivity, relative to literature results for perfluorinated amines, at short values of TE (∼10 ms) in ^19^F SE MRI. These attributes allow ^19^F MRI of PTBD to be performed on standard clinical imaging instrumentation (without special hardware andJor software modification) and an in vivo example in a mouse is shown. This investigation involved characterizing the MR T~1~ and T~2~ relaxation times of PTBD as well as the MR spin‐lattice relaxation rate, R~1~ (1JT~1~), of PTBD as a function of dissolved oxygen concentration. The T~1~ and T~2~ relaxation times and R~1~ relaxation rates of perfluorooctyl bromide (PFOB) were also obtained, under similar experimental conditions, to compare and contrast PTBD with a representative perfluorocarbon that has been widely employed for ^19^F MRIJMRS applications.