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Noninvasive in vivo detection of a fluorinated neuroleptic in the human brain by 19F nuclear magnetic resonance spectroscopy

✍ Scribed by Durst, Philippe; Schuff, Norbert; Crocq, Marc-Antoine; Mokrani, Marie-Claude; Macher, Jean-Paul


Book ID
123206972
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
538 KB
Volume
35
Category
Article
ISSN
0925-4927

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## Abstract __In vivo__ ^19^F NMR measurements of trifluorinated neuroleptics in the rat brain were made using a 13 Γ— 18 mm surface coil at 4.7 T. The signal of fluphenazine was obtained within 8–15 min from brains of living rats treated chronically with drug doses of 5–30 mg/kg. Following the intr

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