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In vivo19F nuclear magnetic resonance of a monofluorinated neuroleptic in the rat

✍ Scribed by Ulrich Günther; Klaus Albert

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
415 KB
Volume
6
Category
Article
ISSN
0952-3480

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✦ Synopsis

In viuo 'q NMR measurements of the fluorinated neuroleptic melperone [4'-fluoro-4-(4-methyIpiperidino)butyrophenone hydrochloride] in the rat brain were performed using a geometrically optimized surface coil at 4.7T. It was possible for the first time to detect a signal of a monofluorinated neuroleptic drug with a time resolution of 30 min after i.p. application. The kinetic time course of the investigated neuroleptic melperone was recorded over 6 h and showed that the half-life in the rat brain is 4.3 h. The total amount of drug and its metabolites in the brain was estimated to be 50 p ~. the chemical shift of the '% NMR signal shows the same upfield shift relative to that in aqueous solution as has been reported for trifluorinated neuroleptic drugs.

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