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In vivo19F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat

โœ Scribed by K. Albert; H. Rembold; G. Kruppa; E. Bayer; M. Bartels; G. Schmalzing

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
363 KB
Volume
3
Category
Article
ISSN
0952-3480

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โœฆ Synopsis

Abstract

In vivo ^19^F NMR measurements of trifluorinated neuroleptics in the rat brain were made using a 13 ร— 18 mm surface coil at 4.7 T. The signal of fluphenazine was obtained within 8โ€“15 min from brains of living rats treated chronically with drug doses of 5โ€“30 mg/kg. Following the intravenous injection of a single dose of trifluoperazine (30 mg/kg), brain levels could be monitored with a time resolution of 30 min. The data demonstrate the possibility of obtaining in vivo pharmacokinetics of fluorinated agents in the rat brain. ^19^F NMR is expected to become an important tool in neurochemical research.

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