In vivo31P nuclear magnetic resonance spectroscopy of rat 9l gliosarcoma treated with BCNU: Dose response of spectral changes
✍ Scribed by R. Grant Steen; Rafael J. Tamargo; Henry Brem; Jerry D. Glickson; Janna P. Wehrle
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 474 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
The 9L gliosarcoma, grown subcutaneously in juvenile Fischer 344 rats, was studied by in vivo "P NMR spectroscopy following treatment with 1,3-bis( 2-chloroethy1)-I-nitrosourea. Dose-dependent increases in the proportion of high-energy phosphates were observed for doses between 10 and 36 mg/kg (from 80% of the LDlo to greater than the LDSo). These doses reduced clonogenic cell survival in a dose-dependent fashion by as much as 3 log orders and resulted in up to 16 days of growth delay (to pretreatment tumor volume). Increases in high-energy phosphates (relative to Pi) in the tumor were greater at higher doses despite the higher levels of clonogenic cell killing and the substantial host Systemic toxicity.