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γ-Lactam analogues of the penems

✍ Scribed by Donald B Boyd; Thomas K Elzey; Lowell D Hatfield; Michael D Kinnick; John M Morin Jr.

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
207 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

Racemic y-lactam analogues of the penems have been prepared and tested for biological activity.

The 7-acylamino derivatives exhibited low levels of antibiotic activity.

📜 SIMILAR VOLUMES

A γ-lactam analogue of penems possessing
A γ-lactam analogue of penems possessing antibacterial activity
✍ Jack E Baldwin; Christopher Lowe; Christopher J Schofield; Eun Lee 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 239 KB

The synthesis of a Y-lactam analogue of the penems, which showed antibacterial activity, is described.

γ-Lactam analogues of carbapenems
γ-Lactam analogues of carbapenems
✍ D.B Boyd; B.J Foster; L.D Hatfield; W.J Hornback; N.D Jones; J.E Munroe; J.K Swa 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 216 KB

Y-Lactam analogues of carbapenems have been synthesized using a [3+2] cyclisation approach. Slight antibiotic activity was observed in one case. S-Lactam antibiotics' mechanism of action involves active site acylation of key enzymes (penicillin binding proteins\_PBP's) required for bacterial cell wa