Y-Lactam analogues of carbapenems have been synthesized using a [3+2] cyclisation approach. Slight antibiotic activity was observed in one case. S-Lactam antibiotics' mechanism of action involves active site acylation of key enzymes (penicillin binding proteins\_PBP's) required for bacterial cell wa
Synthesis of γ-lactam analogues of 1-acetoxy carbapenem derivatives
✍ Scribed by S. Coulton; I. François; R. Southgate
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 161 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A succinct synthesis of a new bicyclic y-lactam designed to possess antibacterial activity containing an oxazolidine ring is described.
The Al-carbapenem derivative(g) was prepared by the aldol condensation of the dialdehydic compound(5) with piperidinium acetate. Careful hydride reduction followed by benzoylation gave zb, which was successfully decarbalkoxylated to 8. The X-ray structure analysis of 8 showed the C-3 carboxylate g
## Abstract The synthesis of some β‐lactams and one Δ^1^‐carbapenem is described. The electronic activation of monocyclic β‐lactams of type **1** is not sufficient to generate a bioactive compound.