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Synthesis of a novel bicyclic γ-lactam analogue of the 1-oxapenams

✍ Scribed by Jack E. Baldwin; Richard T. Freeman; Christopher Schofield

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
139 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

A succinct synthesis of a new bicyclic y-lactam designed to possess antibacterial activity containing an oxazolidine ring is described.

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✍ Claude Agami; Luc Dechoux; Séverine Hebbe 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 226 KB

A study on the reactivity of 3,4-dihydro-2-pyridones 9, derived from (S)-phenylglycinol, toward different bases is presented. Using a catalytic amount of bases, the cis bicyclic lactams were obtained with excellent diastereoselectivities.