A novel stereocontrolled synthesis of enantiopure bicyclic lactams

✍ Scribed by Claude Agami; Luc Dechoux; Séverine Hebbe

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 226 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01209-7

✦ Synopsis

A study on the reactivity of 3,4-dihydro-2-pyridones 9, derived from (S)-phenylglycinol, toward different bases is presented. Using a catalytic amount of bases, the cis bicyclic lactams were obtained with excellent diastereoselectivities.