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A γ-lactam analogue of penems possessing antibacterial activity

✍ Scribed by Jack E Baldwin; Christopher Lowe; Christopher J Schofield; Eun Lee

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
239 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of a Y-lactam analogue of the penems, which showed antibacterial activity, is described.

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γ-Lactam analogues of the penems
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✍ Donald B Boyd; Thomas K Elzey; Lowell D Hatfield; Michael D Kinnick; John M Mori 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 207 KB

Racemic y-lactam analogues of the penems have been prepared and tested for biological activity. The 7-acylamino derivatives exhibited low levels of antibiotic activity.

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A succinct synthesis of a new bicyclic y-lactam designed to possess antibacterial activity containing an oxazolidine ring is described.