𝔖 Bobbio Scriptorium
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β-Amyloid (Aβ); β-site APP-cleaving enzyme 1 (BACE1); mammalian target of rapamycin (mTOR; FRAP; RAFT1)


Book ID
120995392
Publisher
Nature Publishing Group
Year
2013
Weight
116 KB
Volume
6
Category
Article
ISSN
1945-3477

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre