Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides
✍ Scribed by Swahn, Britt-Marie; Kolmodin, Karin; Karlström, Sofia; von Berg, Stefan; Söderman, Peter; Holenz, Jörg; Berg, Stefan; Lindström, Johan; Sundström, Marie; Turek, Dominika; Kihlström, Jacob; Slivo, Can; Andersson, Lars; Pyring, David; Rotticci, Didier; Öhberg, Liselotte; Kers, Annika; Bogar, Krisztian; von Kieseritzky, Fredrik; Bergh, Margareta; Olsson, Lise-Lotte; Janson, Juliette; Eketjäll, Susanna; Georgievska, Biljana; Jeppsson, Fredrik; Fälting, Johanna
- Book ID
- 115449872
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 620 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre