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Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

✍ Scribed by Chiho Hirata-Fukae; Elkhansa Hassan Sidahmed; Thomas P. Gooskens; Paul S. Aisen; Ilse Dewachter; Herman Devijver; Fred Van Leuven; Yasuji Matsuoka


Book ID
116770228
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
322 KB
Volume
435
Category
Article
ISSN
0304-3940

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre