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Hydrogen sulfide reduces mRNA and protein levels of beta-site amyloid precursor protein cleaving enzyme 1 in PC12 cells

✍ Scribed by Hua Zhang; Ying Gao; Fengli Zhao; Zhengwei Dai; Tao Meng; Shengfen Tu; Yong Yan


Book ID
116765599
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
447 KB
Volume
58
Category
Article
ISSN
0197-0186

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre