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The inhibitory effects of different curcuminoids on β-amyloid protein, β-amyloid precursor protein and β-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells

✍ Scribed by Hongying Liu; Zhong Li; Donghai Qiu; Qiong Gu; Qingfeng Lei; Li Mao


Book ID
116772563
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
797 KB
Volume
485
Category
Article
ISSN
0304-3940

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre