Presenilin 1 is involved in the maturati
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Akira Kuzuya; Kengo Uemura; Naoyuki Kitagawa; Nobuhisa Aoyagi; Takeshi Kihara; H
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Article
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2006
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John Wiley and Sons
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English
⚖ 927 KB
## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre