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Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1)

✍ Scribed by Sébastien S Hébert; Valérie Bourdages; Chantal Godin; Mélissa Ferland; Madeleine Carreau; Georges Lévesque


Book ID
117688509
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
332 KB
Volume
13
Category
Article
ISSN
0969-9961

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre