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Splice variants of the β-site APP-cleaving enzyme BACE1 in human brain and pancreas

✍ Scribed by Robert Ehehalt; Beate Michel; Davide De Pietri Tonelli; Daniele Zacchetti; Kai Simons; Patrick Keller

Book ID
117051667
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
474 KB
Volume
293
Category
Article
ISSN
0006-291X

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre