2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

✍ Scribed by Baxter, Ellen W.; Conway, Kelly A.; Kennis, Ludo; Bischoff, François; Mercken, Marc H.; De Winter, Hans L.; Reynolds, Charles H.; Tounge, Brett A.; Luo, Chi; Scott, Malcolm K.; Huang, Yifang; Braeken, Mirielle; Pieters, Serge M. A.; Berthelot, Didier J. C.; Masure, Stefan; Bruinzeel, Wouter D.; Jordan, Alfonzo D.; Parker, Michael H.; Boyd, Robert E.; Qu, Junya; Alexander, Richard S.; Brenneman, Douglas E.; Reitz, Allen B.

• Book ID: 118045880
• Publisher: American Chemical Society
• Year: 2007
• Tongue: English
• Weight: 155 KB
• Volume: 50
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm0705408