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α,α-Difluoro-β-ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B

✍ Scribed by Xianfeng Li; Ashok Bhandari; Christopher P Holmes; Anna K Szardenings


Book ID
108073375
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
275 KB
Volume
14
Category
Article
ISSN
0960-894X

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✍ Q. WANG; Z. HUANG; C. RAMACHANDRAN; A. N. DINAUT; S. D. TAYLOR 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

Naphthalenebis [α,α-difluoromethylenephosphonates] as Potent Inhibitors of Protein Tyrosine Phosphatases. -The desired disubstituted naphthalenes are better protein tyrosine phosphatase inhibitors than the monosubstituted ones. Derivatives (I)-(III) are the most potent inhibitors yet reported. -(WA