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Potent and Highly Selective Inhibitors of the Protein Tyrosine Phosphatase 1B †

✍ Scribed by Taing, Meng; Keng, Yen-Fang; Shen, Kui; Wu, Li; Lawrence, David S.; Zhang, Zhong-Yin


Book ID
120449505
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
208 KB
Volume
38
Category
Article
ISSN
0006-2960

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A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.