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α-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2(2′-carboxyethyl)-6-hydroxychroman, γ-tocopherol metabolite, in rats

✍ Scribed by Chikako Kiyose; Hisako Saito; Kazuyo Kaneko; Kimio Hamamura; Mitsugu Tomioka; Tadahiko Ueda; Osamu Igarashi


Book ID
107485010
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
148 KB
Volume
36
Category
Article
ISSN
0024-4201

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✍ W. Stahl; P. Graf; R. Brigelius-Flohé; W. Wechter; H. Sies 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 74 KB

The metabolites are 2,5,7,8-tetramethyl-2-(2-carboxyethyl)-6-hydroxychroman (␣-CEHC) and 2,7,8-trimethyl-2-(2carboxyethyl)-6-hydroxychroman (␥-CEHC, LLU-␣), respectively. ␣-CEHC is excreted mainly as glucuronide or sulfate conjugates in the urine. Here we describe a sensitive and reliable method to