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Quantification of the α- and γ-Tocopherol Metabolites 2,5,7,8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-Trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in Human Serum

✍ Scribed by W. Stahl; P. Graf; R. Brigelius-Flohé; W. Wechter; H. Sies

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
74 KB
Volume
275
Category
Article
ISSN
0003-2697

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✦ Synopsis

The metabolites are 2,5,7,8-tetramethyl-2-(2-carboxyethyl)-6-hydroxychroman (␣-CEHC) and 2,7,8-trimethyl-2-(2carboxyethyl)-6-hydroxychroman (␥-CEHC, LLU-␣), respectively. ␣-CEHC is excreted mainly as glucuronide or sulfate conjugates in the urine. Here we describe a sensitive and reliable method to analyze ␣and ␥-CEHC in human serum. The concentration of ␣-CEHC in human serum is in the range of 5-10 pmol/ml but increases significantly up to 200 pmol/ml upon supplementation with RRR-␣-tocopherol. About one-third of the ␣-CEHC circulating in the blood is present as a glucuronide conjugate. Baseline levels of ␥-CEHC are about 50 to 85 pmol/ml.

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