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Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (γ-CEHC) in human serum after a single dose of natural vitamin E

✍ Scribed by Dragan Radosavac; Peter Graf; M. Cristina Polidori; Helmut Sies; Wilhelm Stahl

Book ID
106065968
Publisher
Springer
Year
2002
Tongue
English
Weight
256 KB
Volume
41
Category
Article
ISSN
1436-6207

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Quantification of the α- and γ-Tocophero
Quantification of the α- and γ-Tocopherol Metabolites 2,5,7,8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-Trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in Human Serum
✍ W. Stahl; P. Graf; R. Brigelius-Flohé; W. Wechter; H. Sies 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 74 KB

The metabolites are 2,5,7,8-tetramethyl-2-(2-carboxyethyl)-6-hydroxychroman (␣-CEHC) and 2,7,8-trimethyl-2-(2carboxyethyl)-6-hydroxychroman (␥-CEHC, LLU-␣), respectively. ␣-CEHC is excreted mainly as glucuronide or sulfate conjugates in the urine. Here we describe a sensitive and reliable method to