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Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A

✍ Scribed by Rachel Codd; Najwa Braich; Joe Liu; Cho Zin Soe; Amalie A.H. Pakchung

Book ID
116307615
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
367 KB
Volume
41
Category
Article
ISSN
1357-2725

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## Abstract Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single age