✦ LIBER ✦

Zidovudine removal during plasma exchange

✍ Scribed by Dr. F. Fauvelle; A. Leon; O. Petitjean; L. Guillevin

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 280 KB
Volume: 6
Category: Article
ISSN: 0733-2459
DOI: 10.1002/jca.2920060306

No coin nor oath required. For personal study only.

✦ Synopsis

Pharmacokinetics of zidovudine (azidothymidine, AZT) were investigated after oral administration (300 mg every 8 hours) in a human immunodeficiency virus seropositive patient who was also treated with plasma exchange (60 ml/kg). Plasma AZT concentrations were measured using high performance liquid chromatography assay. Plasma exchange clearances reached 1-3.8% of the total clearance. The fraction of AZT removed from separated plasma accounted for only 1% of the administered dose. The contribution of plasma exchange to the elimination of AZT appears to be negligible. Solely on the basis of AZT pharmacokinetic data, no particular dose adjustment appears to be necessary in patients treated with multiple plasma exchanges.

📜 SIMILAR VOLUMES

Phenytoin removal during plasma exchange

✍ Roger L. White; William R. Garnett; Jody H. Allen; Berry J. Kline; David E. Shar 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 345 KB

Plasma exchange is currently being used to treat a variety of disorders including immune complex and hematologic disorders. It has been shown that the removal of plasma removes drugs bound to plasma proteins. This case documents the removal of phenytoin during plasma exchange therapy. Total and free

Diclofenac, paracetamol, and vidarabine

Diclofenac, paracetamol, and vidarabine removal during plasma exchange in polyarteritis nodosa patients

✍ F. Fauvelle; P. Nicolas; A. Leon; M. Tod; G. Perret; O. Petitjean; L. Guillevin 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 564 KB

## Abstract Since plasma exchange (PE) represents a major treatment for patients suffering from systemic diseases, its influence on the kinetics of three drugs was investigated: vidarabine, used in patients with polyarteritis nodosa associated with hepatitis B virus (eight subjects), and diclofenac

Plasma exchange removes glycosphingolipi

Plasma exchange removes glycosphingolipid in Fabry disease

✍ Pyeritz, Reed E. ;Ullman, M. David ;Moser, Ann B. ;Braine, Hayden G. ;Moser, Hug 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB

Aluminium loading during therapeutic pla

Aluminium loading during therapeutic plasma exchange

✍ Felix Monteagudo; Lucille Wood; Peter Jacobs; Peter Folb; Michael Cassidy 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB

Graphite furnace atomic absorption spcctroscopy was used to demonstrate a fivefold increase in thc median plasma aluminium levcls of' four patients undergoing therapeutic plasmapheresis. This plasma aluminium loading resulted from contamination of albumin incorporated in the replacement fluids and t

Pyrogen reactions to human serum albumin

Pyrogen reactions to human serum albumin during plasma exchange

✍ Mark Pool; Bruce C. McLeod 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 420 KB

Reactions to human serum albumin (HSA) in therapeutic plasma exchange (TPE) are rare. Nevertheless, older literature describes possible adverse effects, including specific immune responses to albumin or other proteins, and reactions due to contaminating organisms or pyrogen. During an eight day peri

Management of familial hypertriglyceride

Management of familial hypertriglyceridemia during pregnancy with plasma exchange

✍ Praveen Sivakumaran; Steven W. Tabak; Kimberly Gregory; Samuel H. Pepkowitz; Ell 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB

Hypertriglyceridemia-induced pancreatitis is a serious complication of familial dyslipidemias. Hormonal influences during pregnancy can compromise otherwise controlled lipid levels in women with familial hypertriglyceridemia and predispose to pancreatitis leading to increased morbidity in both mothe