๐”– Bobbio Scriptorium
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Phenytoin removal during plasma exchange

โœ Scribed by Roger L. White; William R. Garnett; Jody H. Allen; Berry J. Kline; David E. Sharp

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
345 KB
Volume
3
Category
Article
ISSN
0733-2459

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โœฆ Synopsis

Plasma exchange is currently being used to treat a variety of disorders including immune complex and hematologic disorders. It has been shown that the removal of plasma removes drugs bound to plasma proteins. This case documents the removal of phenytoin during plasma exchange therapy. Total and free phenytoin serum concentrations were obtained before and after each exchange. Aliquots were obtained from each pass, and total phenytoin concentrations were determined. The total phenytoin serum concentration increased during the first exchange, while the total concentration decreased as a result of the second exchange. It was determined that approximately 27.7 nig and 30.4 mg of phenytoin were removed by the first and second plasma exchanges, respectively.

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