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Aluminium loading during therapeutic plasma exchange

✍ Scribed by Felix Monteagudo; Lucille Wood; Peter Jacobs; Peter Folb; Michael Cassidy

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 230 KB
Volume: 3
Category: Article
ISSN: 0733-2459
DOI: 10.1002/jca.2920030306

No coin nor oath required. For personal study only.

✦ Synopsis

Graphite furnace atomic absorption spcctroscopy was used to demonstrate a fivefold increase in thc median plasma aluminium levcls of' four patients undergoing therapeutic plasmapheresis. This plasma aluminium loading resulted from contamination of albumin incorporated in the replacement fluids and took placc during its preparation. with albumin aluminium levcls of-646. 669, and 71s &liter present in thrce reprcsentative samples. Aluminium overload may result in thc development of enccphalopathy and osteomalacia in patients with rcnal impairment. indicating the need to monitor aluminium levels in the albumin-containing replacement tluids to avoid this potential hazard.

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