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Partial plasma protein replacement in therapeutic plasma exchange

✍ Scribed by Bruce C. McLeod; Richard J. Sassetti; Dusan Stefoski; Floyd A. Davis

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 332 KB
Volume: 1
Category: Article
ISSN: 0733-2459
DOI: 10.1002/jca.2920010209

No coin nor oath required. For personal study only.

✦ Synopsis

We wished to determine whether subtotal replacement of protein in plasma removed at plasma exchange would be adequate to prevent hypovolemia and hypoproteinemia. Seven well nourished outpatients with chronic progressive multiple sclerosis underwent 60 plasma exchanges in which two liters of plasma were replaced with 750 ml saline followed by 1250 ml of a 5 % albumin solution (62.5% albumin replacement). Total serum protein, protein electrophoresis, and immunoglobulin levels were measured before and after each exchange. Clinically, the exchanges were well tolerated. Total serum protein dropped by a mean of only 18% during the study and mean preexchange serum albumin levels were unchanged, even though immunoglobulins decreased by 57-72%. We conclude that in well nourished patients, partial albumin replacement of this magnitude is an adequate substitute for plasma removed in a plasma exchange.

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