๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

X-chromosome polysomy in the male

โœ Scribed by Alice Kleczkowska; Jean-Pierre Fryns; Herman Berghe

Publisher
Springer
Year
1988
Tongue
English
Weight
761 KB
Volume
80
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

โœฆ Synopsis

A review of 569 male patients with X-chromosome polysomies (544 Klinefelter and 25 patients with other types of X-chromosome polysomy) is presented here. These patients were detected among the 77000 persons karyotyped in the Leuven cytogenetic center between the years 1966 and 1987. In the group of 544 Klinefelter patients special attention was paid to (1) the age at diagnosis, (2) social and marital status of the postpubertal males, (3) physical and intellectual abilities of the prepubertal boys, (4) delineation of the concurrence of Klinefelter syndrome and fragile X syndrome, and (5) the frequency of malignancies. In 25 patients with other X-chromosome polysomies (2 n _ 48 chromosomes) genotype/phenotype correlation is reviewed, especially for the patients with 48,XXYY and 49,XXXXY karyotypes. Finally, double aneuploidy and rare structural X-chromosome aberrations are briefly discussed.

๐Ÿ“œ SIMILAR VOLUMES

Parental origin of the extra chromosomes
Parental origin of the extra chromosomes in polysomy X
โœ C. A. Leal; John W. Belmont; Ron Nachtman; J. M. Cantu; C. Medina ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Springer ๐ŸŒ English โš– 402 KB

Five polymorphic index markers were analyzed by polymerase chain reaction (PCR) to ascertain the parental origin of the extra X chromosomes in seven polysomic cases (one 49,XXXXX, three 49,XXXXY, two 48,XXXY, and one 48,XXYY). All four X chromosomes in 49, X polysomies were maternal in origin and th

H-Y antigen in male patients with X poly
H-Y antigen in male patients with X polysomies
โœ Wolfgang Engel; Barbara Klemme; Hans-Dieter Probeck; Christa Fonatsch ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Springer ๐ŸŒ English โš– 245 KB
Fragile X Chromosome in normal males
Fragile X Chromosome in normal males
โœ Daker, M. G. ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 93 KB ๐Ÿ‘ 3 views

## Letter to in Norma To the Editor: the Editor: Fragile X Chromosome Males I found the recent report by Hecht, Jacky, and Sutherland [1982] on the Fragile X Chromosome Workshop (Jerusalem, September 198 1) particularly interesting and a good summary, it seems, of the present situation. However, I

Heteromorphic X Chromosomes in 46,XX mal
Heteromorphic X Chromosomes in 46,XX males?
โœ A. Chapelle; K. Simola; P. Simola; S. Knuutila; N. Gahmberg; L. Pajunen; C. Lund ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› Springer ๐ŸŒ English โš– 859 KB

This paper reports an attempt to determine whether the short arm of one of the X chromosomes in XX males is longer than normal. In a blind study comparing coded photomicrographs of 15 G-banded mitoses from each of five XX males and five control females, the results were ambiguous and somewhat contra