𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Heteromorphic X Chromosomes in 46,XX males?

✍ Scribed by A. Chapelle; K. Simola; P. Simola; S. Knuutila; N. Gahmberg; L. Pajunen; C. Lundqvist; S. Sarna; J. Murros


Publisher
Springer
Year
1979
Tongue
English
Weight
859 KB
Volume
52
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis


This paper reports an attempt to determine whether the short arm of one of the X chromosomes in XX males is longer than normal. In a blind study comparing coded photomicrographs of 15 G-banded mitoses from each of five XX males and five control females, the results were ambiguous and somewhat contradictory, but gave the impression of, or were compatible with, an XXp+ phenomenon in at least two of the five XX males. Measurements of the X chromosomes from the above cells and, in addition, from 15 mitoses from each of six XXY males, failed to disclose any XXp+ phenomenon. Statistical analysis indicated that in the five XX males there was no difference in the lengths of the two Xp arms. The reasons for the apparent discrepancy between the results of ocular inspection and measurement are discussed. The putative heteromorphism might be an alteration in shape, staining intensity, or position of bands, neither of which necessarily leads to an increase in length. We conclude that our results do not indicate any XXp+ phenomenon in the five XX males tested. However, the presence or absence of XXp+ is not in itself evidence for or against interchange betweenthe X and Y in the paternal meiosis. Our results emphasize that the etiology of XX males is likely to be heterogeneous.


πŸ“œ SIMILAR VOLUMES


Short-arm deletion of an X chromosome (4
✍ P. Kaiser; K. Gerhard-Ratschow; B. Zabel; E. Daume πŸ“‚ Article πŸ“… 1977 πŸ› Springer 🌐 English βš– 232 KB

A 31-year-old female patient with short stature, signs of gonadal dysgenesis, and slight Turner signs is described with a mosaic 45,XO/46,XX del (X) (qter leads to p11) determined with trypsin Giemsa-banding and C-staining. BUdR incorporation indicated the deleted X to be late replicating.

Fragile X Chromosome in normal males
✍ Daker, M. G. πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 93 KB πŸ‘ 3 views

## Letter to in Norma To the Editor: the Editor: Fragile X Chromosome Males I found the recent report by Hecht, Jacky, and Sutherland [1982] on the Fragile X Chromosome Workshop (Jerusalem, September 198 1) particularly interesting and a good summary, it seems, of the present situation. However, I