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Parental origin of the extra chromosomes in polysomy X

✍ Scribed by C. A. Leal; John W. Belmont; Ron Nachtman; J. M. Cantu; C. Medina

Publisher: Springer
Year: 1994
Tongue: English
Weight: 402 KB
Volume: 94
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00201605

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✦ Synopsis

Five polymorphic index markers were analyzed by polymerase chain reaction (PCR) to ascertain the parental origin of the extra X chromosomes in seven polysomic cases (one 49,XXXXX, three 49,XXXXY, two 48,XXXY, and one 48,XXYY). All four X chromosomes in 49, X polysomies were maternal in origin and the extra X chromosomes in 48 X polysomies were paternal. In each case the multiple X chromosomes were contributed by a single parent. Taken together with previously reported cases, these data support a single mechanism of sequential nondisjunction during either maternal or paternal gametogenesis as the cause of higher order sex chromosome polysomy.

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