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Workshop: Influence of maternal toxicity in studies on developmental toxicity

✍ Scribed by E.C. Hennes; F. Welsch; B. van Ravenzwaay; H.J. Wiegand

Book ID: 116991797
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 63 KB
Volume: 43
Category: Article
ISSN: 0273-2300
DOI: 10.1016/j.yrtph.2005.06.004

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## Abstract The role of maternal toxicity in lovastatin‐induced developmental toxicity in rats was examined in a series of studies. The first study administered lovastatin at 100, 200, 400, or 800 mg/kg/day (mkd) orally to mated rats from Gestation Day (GD) 6 through 20. Maternal toxicity was obser