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The problem of maternal toxicity in developmental toxicity studies

✍ Scribed by Erminio Giavini; Elena Menegola


Book ID
113965816
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
151 KB
Volume
62
Category
Article
ISSN
0273-2300

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## Abstract The role of maternal toxicity in lovastatin‐induced developmental toxicity in rats was examined in a series of studies. The first study administered lovastatin at 100, 200, 400, or 800 mg/kg/day (mkd) orally to mated rats from Gestation Day (GD) 6 through 20. Maternal toxicity was obser