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Wild-type p53 activates SAP expression in lymphoid cells

✍ Scribed by Nagy, N; Takahara, M; Nishikawa, J; Bourdon, J C; Kis, L L; Klein, G; Klein, E


Book ID
110068975
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
283 KB
Volume
23
Category
Article
ISSN
0950-9232

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The p53 tumor-suppressor gene is the most commonly mutated gene in cancer. However, p53 gene alterations are infrequent in renal-cell cancer (RCC). Bcl-2 has been shown to inhibit apoptosis triggered by wild-type p53 and an inverse correlation between Bcl-2 expmrion and p53 mutation has been observe