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Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein

✍ Scribed by Vinyals, A; Peinado, M A; Gonzalez-Garrigues, M; Monzó, M; Bonfil, R D; Fabra, A

Book ID
110038329
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
355 KB
Volume
6
Category
Article
ISSN
0969-7128

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## Abstract ## Background. In the majority of human cancers, the tumor suppressor activity of p53 is impaired because of mutational events or interactions with other proteins (ie, MDM2). The loss of p53 function is responsible for increased aggressiveness of cancers, while tumor chemoresistance an