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Endogenous p53 gene status predicts the response of human squamous cell carcinomas to wild-type p53

✍ Scribed by St. John, Lisa S; Sauter, Edward R; Herlyn, Meenhard; Litwin, Samuel; Adler-Storthz, Karen


Book ID
110017701
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
198 KB
Volume
7
Category
Article
ISSN
0929-1903

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In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent clonin